在瘤学人群中,药物不良反应和药物相关问题与支持性护理药物有关
Batoul Barari Tajani1, E Maheswari2, Vinayak V Maka3
1Department of Pharmacy Practice, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India. shiva1452@gmail.com.
Discover oncology
|September 9, 2024
概括
癌症患者的支持性护理药物经常导致不良药物反应 (ADR) 和与药物相关的问题 (DRP),影响治疗结果. 监测这些药物对于改善患者管理和治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
- 临床药房 临床药房
背景情况:
- 支持性护理药物对于接受化疗的癌症患者至关重要.
- 与这些药物相关的药物不良反应 (ADR) 和药物相关问题 (DRP) 可以显著影响患者的结果.
- 需要对这些药物的全面评估,以优化癌症患者的管理.
研究的目的:
- 评估癌症患者因支持性护理药物引起的不良药物反应 (ADR) 和与药物有关的问题 (DRP) 的影响.
- 评估与支持性护理药物相关的副作用的因果关系,严重性,可预测性和可预防性.
- 通过更好地监测辅助药物,为改善患者管理和治疗结果提供见解.
主要方法:
- 在印度的Ramaiah医学院医院进行了一项纵向观测研究.
- 关于支持性护理药物,ADR和DRP的数据使用标准化表格收集.
- 已建立的评估尺度 (WHO,Naranjo,Hartwig & Siegel,Rawlins & Thompson,Shumock & Thornton) 和PCNE标准被用于评估.
主要成果:
- 在302名注册患者中,175人 (57.9%) 经历了副作用,153人 (50.6%) 患有与支持性护理药物相关的DRP.
- 因果关系评估表明,在32.1%的病例中可能出现副作用,而31.5%的病例是轻微的,20.9%的病例是中度严重的.
- 在副作用和酒精消费状态 (P=0.019) 和 ECOG性能状态 (P<0.001) 之间发现了显著的关联.
结论:
- 支持性护理药物的不良药物反应在癌症患者中很常见,可能会对治疗产生负面影响.
- 对辅助药物的全面评估和监测对于改善患者管理和治疗结果至关重要.
- 医疗保健专业人员应警监测接受支持性护理药物的患者,以减轻潜在的风险.
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