放射治疗对术后乳房的影响的定量评估
Miriam Becker1, McKay Reese1, Andrea Yessaillian1
1From the School of Medicine.
Plastic and reconstructive surgery
|September 9, 2024
概括
接受放射治疗的乳腺癌患者经历了显著的乳腺体积损失,在一年内损失约20%,并在治疗后长达五年内继续损失体积.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 整形外科 整形外科 整形外科
背景情况:
- 放射治疗 (RT) 后的乳房体积变化可能会影响乳房保护疗法 (BCT) 的结果.
- 关于RT后乳腺体体积损失的程度和时间的定量数据是有限的.
研究的目的:
- 为量化治疗T1瘤BCT和RT的患者的乳腺体积损失.
- 评估治疗后乳房体积变化的时间和预测因素.
主要方法:
- 从113名患者 (115个乳房) 的乳房显微镜计算的乳房体积变化,直到7年后的乳房切除和RT.
- 利用体积计算和统计分析,包括对对 t 试验和多变量回归.
- 根据瘤/乳腺体积和患者年龄,吸烟和糖尿病等因素进行子集分析.
主要成果:
- 患者通过手术失去了8.3%的乳房体积,在BCT/RT后的一年内,总体积损失达到19.3%,在BCT/RT后的5年内达到26.6%.
- 较大的基线乳房体积,糖尿病和吸烟史是较大体积损失的重要预测因素.
- 根据最初的瘤/乳腺体积,子组之间体积损失没有显著差异.
结论:
- 在T1瘤的BCT/RT之后,乳腺体积的减少是相当大的,在第一年内平均约为20%,持续5年.
- 虽然基线乳房体积没有显著改变体积变化百分比,但较大的乳房可能会显示出更大的绝对体积减少.
- 了解这些体积变化对于管理患者的期望和优化乳腺癌治疗后的审美和功能结果至关重要.
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