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频繁使用可卡因与更大的HIV潜伏水库大小有关

Bradley E Aouizerat^1,2, Josephine N Garcia^1,2, Carlos V Domingues^1,2

¹Department of Oral and Maxillofacial Surgery, New York University.

Journal of acquired immune deficiency syndromes (1999)

|September 9, 2024

概括

可卡因使用与艾滋病毒感染妇女 (PLWH) 的更大的艾滋病毒潜伏储备有关. 这项研究强调了非法药物使用对该人口艾滋病毒进展和死亡率的影响.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
病毒学病毒学

背景情况:

在艾滋病毒感染者 (PLWH) 中,可卡因滥用很普遍.
可卡因使用与较差的HIV健康结果有关,包括更高的病毒载量和死亡率.
了解可卡因对艾滋病毒潜伏库的影响对于治疗策略至关重要.

研究的目的:

研究可卡因使用对病毒抑制的PLWH中CD4+T细胞HIV潜伏储存库 (HLR) 的影响.
分析基于当前,以前和从未使用过可卡因的库存大小差异.

主要方法:

对美国国家队列中的434名女性CD4+T细胞基因组DNA的分析.
使用 Intact Proviral HIV DNA Assay,对每10^6个CD4+T细胞进行完整的前病毒的量化.
参与者的分层分为目前的可卡因使用者,以前的使用者和从未使用者.

主要成果:

过去和现在的可卡因使用者与从未使用者相比,艾滋病毒潜伏水库大小显著更大.
从未使用者中,HLR的中位数为72 (IQR: 14-193),之前使用者为165 (IQR: 63-387),目前使用者为184 (IQR: 28-502).
这些差异具有统计学意义 (P=0.023对于以前的用户,P=0.001对于当前的用户).

结论:

可卡因使用可能会增加CD4+T细胞中具有复制能力的HIV潜伏储存库的大小.
鉴于女性在艾滋病毒储存库研究中的代表性不足,这些发现具有意义.
需要进一步的研究,以了解可卡因使用对女性艾滋病毒储库动态的临床影响.

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