睡眠,睡眠呼吸暂停和疲劳在艾滋病毒感染者的生活
Jeremy E Orr1, Jazmin Velazquez1, Christopher N Schmickl1
1Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA.
Journal of acquired immune deficiency syndromes (1999)
|September 9, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在艾滋病毒感染者 (PLWH) 中很常见,会引起嗜睡,但不会导致疲劳. 睡眠时间的变化,而不是OSA,预测了PLWH中的疲劳.
科学领域:
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
- 艾滋病毒研究 艾滋病毒研究
背景情况:
- 艾滋病毒感染者 (PLWH) 经常经历疲劳,尽管病毒载量被抑制.
- 阻塞性睡眠呼吸暂停 (OSA) 在PLWH中很普遍,与疲劳有关,但其解释疲劳的作用尚不清楚.
研究的目的:
- 为了调查阻塞性睡眠呼吸暂停 (OSA) 和艾滋病毒感染者 (PLWH) 疲劳之间的关联.
- 确定导致PLWH疲劳和嗜睡的因素.
主要方法:
- 招募了PLWH (年龄在18-65岁之间,BMI在20-35公斤/米2,病毒抑制) 进行问卷调查 (FACIT-Fatigue,ESS),7天的动图和多睡眠图.
- 使用美国睡眠医学学会的标准评估了OSA的存在和严重程度.
主要成果:
- 75%的PLWH (90/120) 患有OSA.
- OSA与白天睡眠增加有关 (爱普沃思睡眠度量表),但没有疲劳 (FACIT-疲劳度量表).
- 疲劳是由可变的睡眠时间和活动减少预测的; 嗜睡是由OSA预测的.
结论:
- 在PLWH中,OSA非常普遍,与嗜睡相关,但与疲劳无关.
- 睡眠时间的变化与这一群体的疲劳增加有关.
- 进一步的研究应该探索OSA治疗和睡眠的一致性,以管理PLWH的疲劳.
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