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Updated: Jun 13, 2025

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AMAR-seq:通过单细胞分辨率对DNA甲基化,染色质可访问性和RNA表达的自动化多模式测序

Xi Zeng1, Xiaoping Yang1, Zhixing Zhong1

  • 1The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical of Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemical Biology, Department of Chemical Engineering, College of Chemistry and Chemical Engineering and Institute of Artificial Intelligence, Xiamen University, Xiamen 361005, China.

Analytical chemistry
|September 9, 2024
PubMed
概括

我们开发了AMAR-seq,这是一种用于单细胞多组学分析的自动化方法,集成甲基化,染色质可访问性和RNA表达. 这种强大的工具揭示了细胞分化过程中的动态表观遗传和转录组合.

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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