在选择口腔疾病中,氨酸- ангиотензин系统的新兴作用
Yixing Liu1, Zhe Liu1,2
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
Oral diseases
|September 9, 2024
概括
氨酸- ангиотензин系统 (RAS) 影响口腔健康,影响口腔状细胞癌 (OSCC),牙周炎和味觉障碍. 在RAS信号中的失衡可能会使这些口腔疾病变得更糟.
科学领域:
- 心血管生理学心血管生理学
- 口腔生物学 口腔生物学
- 病理学 病理学 病理学
背景情况:
- 氨酸- ангиотензин系统 (RAS) 对于心血管和脏调节至关重要.
- RAS成分存在于口腔组织中,但它们在口腔疾病中的作用尚不清楚.
- 本综述重点关注RAS对口腔状细胞癌 (OSCC),牙周炎,口腔下纤维化 (OSF) 和味道变化的影响.
研究的目的:
- 审查目前关于氨酸- ангиотензин系统 (RAS) 在特定口腔疾病中的作用的文献.
- 综合RAS组件及其在OSCC,牙周炎,OSF和ageusia/dysgeusia中的信号通路的已知影响.
主要方法:
- 通过使用PubMed,Web of Science和Scopus数据库进行了全面的文献搜索,直到2024年7月.
- 采用叙事审查方法来综合和总结所选研究的发现.
主要成果:
- 在OSCC中,ACE/Ang II/AT1R轴促进癌症,而ACE/Ang II/AT2R和ACE2/Ang (1-7) /MasR途径则抑制癌症.
- 对于牙周炎,ACE/Ang II/AT1R会加剧炎症和骨质损失,而ACE2/Ang (1-7) /MasR则提供保护.
- ангиотензин (1-7) [Ang (1-7) ] 抵消了Ang II在OSF中的作用,并调节了ageusia/dysgeusia的味觉感知.
结论:
- 氨酸 - ангиотензин系统 (RAS) 级联显著影响OSCC,牙周炎,OSF和味觉障碍的发病.
- RAS通路的调节失调可能会加剧这些口腔疾病的进展和严重程度.
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