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相关概念视频

Knee Joint01:23

Knee Joint

1.6K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
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Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

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The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
2.3K
Ankle Joint01:10

Ankle Joint

1.5K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.5K
Muscles that Move the Leg01:23

Muscles that Move the Leg

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The movement of the legs is facilitated by numerous muscles located within the anterior, medial, and posterior compartments of the thigh.
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
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相关实验视频

Updated: Jun 13, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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膝盖骨关节炎 膝盖骨关节炎

Allan C Gelber1

  • 1Johns Hopkins University School of Medicine, Baltimore, Maryland (A.C.G.).

Annals of internal medicine
|September 9, 2024
PubMed
概括
此摘要是机器生成的。

膝关节骨关节炎 (OA) 导致关节疼痛和硬,超重是关键的危险因素. 虽然治疗有助于控制症状,但手术只适用于对保守疼痛管理无反应的病例.

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科学领域:

  • 整形外科 整形外科 整形外科
  • 类风湿病学 类风湿病学
  • 老年学是一门学科.

背景情况:

  • 膝关节关节炎 (OA) 是一种退行性关节疾病,其特点是疼痛,硬和功能下降.
  • 肥胖和超重被确定为重要的可修改的风险因素,有助于膝盖骨关节炎的发展和进展.
  • 目前的治疗方法提供症状缓解,但不能阻止潜在的病理性关节变化.

研究的目的:

  • 总结膝关节骨关节炎的临床表现,风险因素和管理原则.
  • 概述药理和非药理干预措施在管理膝关节OA症状中的作用.
  • 确定在晚期膝关节OA病例中进行手术干预的标准.

主要方法:

  • 对有关膝关节骨关节炎的现有文献的综述.
  • 临床表现和诊断特征的分析.
  • 评估当前的治疗策略,包括保守和手术选择.

主要成果:

  • 膝关节OA呈现出活动加剧的疼痛和短暂的早晨硬,没有宪法症状.
  • 体重管理对于减轻OA风险和进展至关重要.
  • 药物和非药物治疗可以改善疼痛和功能,但不能逆转疾病病理.

结论:

  • 保守的管理是膝关节OA治疗的基石.
  • 外科干预适用于对非手术方法耐药的疼痛和功能障碍.
  • 解决肥胖等可修改的风险因素对于长期的膝关节OA管理至关重要.