在小鼠中脂质体封装的阿普罗丁因生物分布:与自由药物配方并排比较
Elizaveta N Mochalova1, Vladimir R Cherkasov2, Artem A Sizikov3
1Moscow Institute of Physics and Technology, 1А Kerchenskaya St, 117303, Moscow, Russia; Sirius University of Science and Technology, 1 Olimpiyskiy Ave, 354340, Sirius, Krasnodar region, Russia; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St, 119991, Moscow, Russia.
与其分子形式相比,脂质体中蛋白质蛋白在肺部,心脏和脏中的积累增加. 这种改善的生物分布表明,在影响这些器官的病毒感染中,可能会产生更长的治疗效果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米医学是一种纳米医学.
- 病毒学 病毒学
背景情况:
- 病毒性呼吸道感染可能会导致严重的长期健康问题,而COVID-19等大流行病会加剧这种问题.
- 作为一种抗纤维解质蛋白酶抑制剂的阿普罗丁因在抑制病毒复制方面表现有前途.
- 脂质体封装可能会增强aprotinin的有效性并改变其生物分布.
研究的目的:
- 为了比较脂质体中蛋白质的生物分布与分子蛋白质的生物分布.
- 评估脂质体中蛋白的治疗病毒感染和相关器官损伤的潜力.
主要方法:
- 合成具有不同组成的脂质体.
- 对脂质体和分子蛋白质的光标签.
- 在小鼠中进行ex vivo生物成像,以追踪肺部,心脏和脏中的生物分布.
主要成果:
- 与自由蛋白相比,脂类蛋白质在目标器官中的积累量显著增加:肺中的1.82倍,心脏中的3.56倍和脏中的2.00倍.
- 脂质体在这些器官中停留时间较长.
结论:
- 与其分子形式相比,脂质体蛋白质提供了优越的生物分布和器官积累.
- 带有阿普罗丁因的脂质体具有治疗病毒性呼吸道损伤和相关心脏和脏并发症的巨大潜力.
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