产前暴露于环境空气污染和持续的产后抑郁症
Yuhong Hu1, Zhongzheng Niu1, Sandrah P Eckel1
1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
The Science of the total environment
|September 9, 2024
概括
产前暴露于二氧化 (NO2) 和颗粒物10 (PM10) 显著增加了持续产后抑郁症的风险,长达三年. 怀孕中期暴露于空气污染是孕妇长期心理健康的关键因素.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 围产期心理健康问题
背景情况:
- 产前暴露于环境空气污染与产后抑郁症有关,长达12个月.
- 很少有研究检查空气污染对产后12个月以上抑郁症的影响.
研究的目的:
- 评估产前环境空气污染暴露与产后3年持续抑郁风险之间的关联.
- 为了确定孕期暴露于空气污染物的敏感窗口.
主要方法:
- 该研究包括来自MADRES队列的361名低收入西班牙裔/拉丁裔参与者.
- 怀孕期间估计的每日住宅PM2.5,PM10,NO2和O3度.
- 在产后12,24和36个月使用CES-D尺度评估抑郁症;持续性抑郁症定义为CES-D得分≥16在任何时间点.
- 通过通用估计方程 (GEE) 使用了强大的Poisson日志线性分布式滞后模型 (DLM).
主要成果:
- 在13-29周的妊娠期间,产前暴露于NO2的IQR增加 (3.9ppb) 与持续产后抑郁症的风险增加3.86倍有关.
- 在12-28周妊娠期间,产前暴露于PM10的IQR增加 (7.4μg/m3) 与持续产后抑郁症的风险增加3.88倍有关.
- 没有发现PM2.5或O3.5的透明敏感窗口.
结论:
- 怀孕中期暴露于PM10和NO2与持续性产后抑郁症的风险增加近4倍有关.
- 这些发现强调了空气污染对围产期心理健康预防策略的关键影响.
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