氨酸修饰的聚乙乙空心纤维膜,具有改善的血液兼容性和空气透性,用于体外膜氧化
Shangbo Li1, Shiyi Zhou1, Xiangpu Qin2
1College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China.
International journal of biological macromolecules
|September 9, 2024
概括
聚乙空腔纤维膜 (PEEK-HFM) 用氨酸或合成氨酸类层进行修改,以提高外体膜氧化 (ECMO) 装置的生物相容性. 这两种修改都成功地减少了血小板粘附,并改善了抗凝性质,为当前材料提供了可行的替代品.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 医疗设备工程 医疗设备工程
背景情况:
- 聚 (4-甲基-1-) 空心纤维膜 (PMP-HFM) 目前用于体外膜氧化 (ECMO).
- 聚乙空腔纤维膜 (PEEK-HFM) 提供了潜在的优势,但需要表面修改以解决血小板粘附和血泄漏等生物相容性问题.
研究的目的:
- 在ECMO应用中评估PEEK-HFM作为PMP-HFM的替代品.
- 通过使用氨酸和合成氨酸类层进行表面修改,提高PEEK-HFM的血液相容性.
- 评估合成氨酸类层作为天然氨酸的替代品的有效性.
主要方法:
- 使用紫外线照射将天然氨酸移植到PEEK-HFM上.
- 在PEEK-HFM上使用乙酸和p-styrenesulfonate的共聚物构建一个类似氨酸的层.
- 对修改膜的表面特性,血小板粘附性和抗凝行为进行评估.
主要成果:
- 氨酸移植和氨酸样改造的PEEK-HFMs都显示出孔隙参数减少,但表面水友性得到改善.
- 表面的修改有效地防止了血小板粘附,并增强了抗凝性质.
- 氨酸修饰和氨酸类似修饰的PEEK-HFMs表现相似,表明合成层的有效性.
结论:
- 经过修改的PEEK-HFM是ECMO生产中商业PMP-HFM的可行替代品.
- 合成的氨酸类层可以有效地替代氧化器的膜修改中的天然氨酸.
- 这项研究为开发用于氧化器应用的先进膜提供了重要的见解.
相关概念视频
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
968
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
968
01:25Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
345
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
345
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
369
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
369
01:24Hemodialysis II: Procedure and Complications
1.9K
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.9K