血管硬,脑动脉瘤和手术结果的手术内替代品之间的关系
Shu Zhang1, Rafael J Tamargo2, Jules Bergmann1
1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
概括
动脉硬度替代物,如门诊动脉硬度指数和脉冲压在脑动脉瘤患者中升高. 虽然最初与糟糕的结果有关,但多变量分析表明年龄是一个更强的预测因素,突出了仅使用刚度测量来预测结果的局限性.
科学领域:
- 血管外科 血管外科
- 神经学 神经学
- 心脏病学 心脏病学
背景情况:
- 增加的动脉硬与系统和大脑循环中的动脉瘤形成有关.
- 动脉硬在脑血管系统中的确切作用需要进一步阐明.
研究的目的:
- 评估手术内动脉硬的替代品是否在脑动脉瘤患者和对照人群之间有所不同.
- 确定这些指数与开放性手术治疗后的结果之间的关系.
主要方法:
- 对接受脑动脉瘤手术的患者与对照患者的评估.
- 动脉硬度的估计使用手术期间的门诊动脉硬度指数 (AASI) 和平均脉压 (PP).
主要成果:
- 与对照组 (n=234) 相比,动脉瘤患者 (n=214) 显示AASI和PP升高.
- AASI和PP与不良的神经结果相关,但不是下关节出血 (SAH).
- 多变量分析显示年龄是关键预测因素,减少了AASI和PP与结果的关联.
结论:
- 术内动脉硬替代品表明其在脑动脉瘤疾病中的存在,并可能影响临床过程.
- 动脉硬度测量在独立预测临床结果方面存在局限性.
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