在中部前额叶皮层中,结构性协差网络活动是由抑郁症青少年的童年虐待所调节的
Zhanjie Luo1, Weicheng Li1, Zhibo Hu2
1The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Child and Adolescent Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China.
在患有严重抑郁症的青少年中,童年虐待显著改变了大脑结构. 介面前额皮层和前额边缘系统的这些变化会影响情绪处理和神经发育.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 中间前额叶皮层 (mPFC) 的异常结构共变性 (SC) 与青少年出现的大型抑郁症 (AO-MDD) 有关.
- 童年虐待 (CA) 对mPFC SC在AO-MDD中的特定影响仍然在很大程度上未被探索.
研究的目的:
- 在AO-MDD患者的mPFC中调查异常SC.
- 评估mPFC SC在AO-MDD中的CA的潜在调制.
主要方法:
- 从AO-MDD患者 (n=93) 和健康对照 (HCs,n=81) 获取T1加权的结构MRI图像.
- 基于voxel的形态测量 (VBM) 分析,以计算灰色物质体积.
- 异常mPFCSC的分类,根据CA的严重程度分为亚型.
主要成果:
- 在默认模式网络 (DMN) 的关键区域mPFC中,AO-MDD患者表现出改变的结构共变网络.
- 在DMN的结构共变连接中观察到前后解离.
- 童年虐待调节了双边mPFCSC,特别是mPFC和边缘系统之间,表明成熟异步.
结论:
- 对于情绪处理至关重要的DMN和前边缘系统在AO-MDD的发展中起着重要作用.
- 童年虐待对AO-MDD患者观察到的神经生理学变化有很大影响.
- 这些发现强调了CA在塑造AO-MDD中大脑结构和功能的关键作用.
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