视网膜输入到的上层结膜来源于向侧生殖细胞核投射的分支轴突
Yicen J Zheng1, Daniel L Adams1, Thomas N Gentry1
1Program in Neuroscience, Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143.
概括
大多数向侧面生殖细胞核投射的视网膜质细胞也会向的上层结核发送附带分支. 大约5%的这些细胞提供了这种双层内化,没有细胞专门投射到上层.
科学领域:
- 神经科学是一个神经科学.
- 视觉科学科学 视觉科学
- 灵长类的视网膜电路系统
背景情况:
- 视网膜质细胞 (RGCs) 投射到各种大脑点,包括上结核 (SC) 和侧结核 (LGN).
- 在灵长类动物中,个别RGC对SC和LGN的投射程度在很大程度上仍未被描述.
研究的目的:
- 调查那些向SC投射的相同的RGC是否也向LGN投射.
- 确定对两个目标有不同的预测的RGC的比例.
主要方法:
- 在两只雄性身上进行了双标签逆行追踪实验.
- 与不同的光标记物 (Alexa Fluor 488和555) 相结合的霍乱毒素B子单位 (CTB) 被注射到SC和LGN在匹配的视网膜位点.
- 在视网膜平装中的RGC被检查是否有双重标记.
主要成果:
- 投射到SC的RGC的很大一部分 (76-98%) 也被标记为注入到LGN的注入,表明了抵押预测.
- 投射到SC的RGC约占标记RGC总人口的4.0-6.7%.
- 没有发现任何RGC仅向SC投射,所有SC投射细胞也向LGN投射.
结论:
- 对子SC的视网膜输入来源于RGCs的附带轴突分支,这些分支主要向LGN投射.
- 这表明灵长类动物中视觉信息处理通路到SC和LGN的视觉信息处理通路有显著的重叠,由RGCs的一个子集介导.
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