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Updated: Jun 13, 2025

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量化预测运动对药物的药理动力学的影响,使用基于生理的药理动力学模型

Zeyu Guo1, Jingjing Gao1, Li Liu2

  • 1Department of Pharmacology, China Pharmaceutical University, Nanjing, China.

Drug metabolism and disposition: the biological fate of chemicals
|September 9, 2024
PubMed
概括

这项研究创建了一个数据库和模型来预测运动如何影响药物药理动力学,显示运动强度和持续时间显著影响体内的药物水平.

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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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