在撒哈拉以南非洲长期COVID成年人的动脉硬
Chikopela Theresa1, Bwalya Katebe1, Cyndya A Shibao2
1Department of Human Physiology, Faculty of Medicine, Lusaka Apex Medical University, Lusaka, Zambia.
Physiological reports
|September 9, 2024
概括
与健康个体相比,长期COVID患者的成年人表现出动脉硬度增加. 这一发现表明,持续的SARS-CoV-2症状与心血管风险之间存在潜在的联系,突出了进一步研究的必要性.
科学领域:
- 心血管科学 心血管科学
- 传染病流行病学 传染病流行病学
- 临床生理学 临床生理学
背景情况:
- 严重的急性冠状病毒-2 (SARS-CoV-2) 感染与内皮损伤和氧化物生产受损有关,增加心血管疾病的风险.
- 长期COVID的特征是感染后持续或出现新的症状,与动脉硬有未知的关联.
- 动脉硬是心血管事件的预测因素,受内皮功能的影响.
研究的目的:
- 在年轻成年人中调查动脉硬与长期COVID之间的联系.
- 将长期COVID患者的动脉硬度与年龄和性别匹配的对照进行比较.
主要方法:
- 这是一项观察性,横截面研究,涉及74名参与者 (53名长期COVID患者,21名对照者),年龄在19-40岁之间.
- 动脉硬度是用心血管-辐射脉冲波速率 (crPWV) 和心血管-辐射动脉硬度指数 (crASI) 通过 Complior 分析单元协议进行测量.
- 数据收集发生在急性COVID-19感染后1-9个月.
主要成果:
- 与对照组相比,长期COVID组的crPWV (10 m/s IQR 8.5-11.2对比8.8 m/s IQR 7.7-9.2) 和crASI (2.26 cm/ms IQR 1.9-2.56对比2.01 cm/ms IQR 1.82-2.27) 显著更高 (p <0.05).与对照组相比,长期COVID组的crPWV (10 m/s IQR 8.5-11.2对比8.8 m/s IQR 7.7-9.2) 和crASI (2.26 cm/ms IQR 1.9-2.56对比2.01 cm/ms IQR 1.82-2.27) 显著更高.
- 患有长期COVID的参与者显示A型波形的患病率更高,表明动脉硬化增加.
- 在长期COVID的成年人中,外周动脉硬度升高.
结论:
- 长期COVID的成年人经过急性感染数月后,表现出外围动脉硬度增加.
- 长期COVID患者的动脉硬度升高表明潜在的长期心血管并发症.
- 需要进一步的研究,以了解长期COVID中动脉硬的机制和临床影响.
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