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乳腺癌复发与检测方式相关:对个性化监测的影响

Hanna Sartor^1,2, Oskar Hagberg¹, Oskar Hemmingsson³

¹Department of Translational Medicine, Diagnostic Radiology, Lund University, Lund, Sweden.

Breast cancer research and treatment

|September 9, 2024

概括

大多数乳腺癌复发是在例行随访之外被检测出来的. 根据患者年龄和瘤类型量身定制的基于风险的监测可以改善早期检测局部复发 (LR) 和第二原发性 (SP) 乳腺癌.

科学领域:

在瘤学瘤学.
乳腺癌研究研究乳腺癌研究
临床监督临床监督

背景情况:

目前的乳腺癌随访指南缺乏经过证明的有效性.
定制的监测策略可以提高复发的早期检测.
患者的年龄和瘤特征是个性化随访的潜在因素.

研究的目的:

确定在计划监测之外检测到的双侧局部区域性复发 (LR) 和第二原发性 (SP) 乳腺癌的频率.
识别与检测计划后续之外的复发相关的风险因素.

主要方法:

从两个队列 (MDCS和Västernorrland地区) 的早期乳腺癌患者的回顾性分析.
包括1080名 (MDCS) 和1648名 (Västernorrland) 手术治疗的患者.
收集关于临床,病理信息和复发检测模式 (计划监测内或外) 的数据.

主要成果:

随访时间中位数为6.5年;461名患者出现了复发.
远程转移是最常见的事件 (47%),其次是LR (22%) 和SP (18%).
56%的LR和28%的SP在监测之外被检测出来. 年龄较小 (<50岁),淋巴结阳性状态和HER2阳性亚型增加了外部监测检测的几率.

结论:

大多数乳腺癌复发,特别是LR,在计划监测协议之外被发现.
基于风险的监测,考虑个体患者和瘤因素,可能对某些患者群体更有效.
个性化监测策略可以改善乳腺癌幸存者的结果.

关键词:

乳腺癌是什么? 乳腺癌是什么?地方地区复发情况.个性化的后续跟踪.第二种原发性乳腺癌.监督监督监督监督监督监督监督监督监督监督监督监督

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