叶酸作为一种潜在的维生素在血糖控制:一个系统的审查
Gökçe Sueda Aydoğdu1, Buket Akyakar2, Zeynep Kalaycı3
1Department of Nutrition and Dietetics, Faculty of Health Sciences, Anadolu University, Eskişehir, Turkey. gokcesuedaaydogdu@anadolu.edu.tr.
Current nutrition reports
|September 9, 2024
概括
叶酸补充剂有望改善血糖控制,降低成年人的禁食血糖,胰岛素水平和HOMA-IR. 然而,需要更多的研究来证实对HbA1c的长期影响和影响.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 血糖控制对于管理糖尿病和预防并发症至关重要.
- 叶酸在各种代谢过程中发挥作用,但其对血糖控制的直接影响需要进一步研究.
- 现有的研究对叶酸状况和血糖参数之间的关联提出了不同的发现.
研究的目的:
- 系统地审查血清叶酸水平和叶酸补充剂与关键血糖控制标志物之间的关系.
- 分析对成人的空腹血糖 (FBG),胰岛素水平,胰岛素耐药性恒温模型评估 (HOMA-IR) 和血红蛋白A1c (HbA1c) 的影响.
主要方法:
- 通过使用主要科学数据库 (Web of Science,Science Direct,Medline,Wiley,Cochrane Library) 进行了对研究的系统审查.
- 搜索是在2023年4月至5月和2023年10月至11月期间进行和更新的.
- 从对1855篇文章的初步选中,包括了17项研究,该协议注册在PROSPERO.
主要成果:
- 大多数横截面研究发现血清叶酸和血糖控制参数之间没有显著的相关性.
- 然而,随机对照试验表明,随着叶酸补充,FBG,胰岛素和HOMA-IR显著减少.
- 限制包括研究时间短,HbA1c的评估不足,阻碍了对长期影响的结论.
结论:
- 叶酸补充剂可以改善成年人的某些血糖控制标志物,特别是短期禁食葡萄糖和胰岛素抵抗.
- 仅仅血清叶酸水平在观察性研究中并没有显示出与血糖控制的一致关联.
- 需要进一步的全面研究,包括评估HbA1c的更长的试验,以确定叶酸在血糖管理中的作用的最终结论.
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