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基于大脑复杂性的精神分裂症患者的异常大脑活动和治疗反应的神经成像标志物

Liju Liu¹, Zezhi Li², Di Kong¹

¹The Fourth People's Hospital of Chengdu, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, PR China.

Translational psychiatry

|September 9, 2024

概括

精神分裂症 (SZ) 患者表现出脑活动复杂性降低和异常动态变化,影响认知. 抗精神病治疗部分恢复了复杂性,这表明了治疗的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

大脑活动的复杂性对于信息处理和适应至关重要.
精神分裂症 (SZ) 与大脑功能的改变有关,但其对复杂性动态的影响尚不清楚.

研究的目的:

为了研究药物原始的第一期SZ患者的大脑活动复杂性模式.
探索复杂性,认知缺陷和抗精神病治疗反应之间的关系.

主要方法:

使用功能性MRI (fMRI) 进行滑动窗口分析和加权 permutation entropy.
评估了44名SZ患者和30名健康对照 (HC) 在Risperidone治疗12周前后.

主要成果:

与HC患者相比,SZ患者在基底 (尾,尾,尾) 中的复杂性降低了.
减少左尾骨复杂性与认知缺陷相关,并在治疗后得到改善.
动态复杂性"下降"在SZ患者中减少,但随着治疗而改善,与认知功能和症状严重程度相关.

结论:

大脑活动复杂性及其动态的异常可能是SZ认知和临床症状的基础.
抗精神病治疗部分地使这些异常正常化,表明治疗疗效和个性化治疗的潜在生物标志物.

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