埃及儿童无并发型1型糖尿病的营养状况和扩展代谢查
Hala M Sakhr1, Mohammed H Hassan2, Ahmed El-Abd Ahmed3
1Department of Pediatrics, Qena Faculty of Medicine, South Valley University, Qena, Egypt. hala.sakhr@med.svu.edu.eg.
患有1型糖尿病 (T1DM) 的儿童显示氨基酸和卡尼丁代谢发生变化,影响生长和血糖控制. 营养评估对于治疗儿童T1DM至关重要.
科学领域:
- 生物化学 生物化学
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
背景情况:
- 营养状况对于1型糖尿病 (T1DM) 的儿童的生长和代谢调节至关重要.
- 评估氨基酸,卡尼丁和基卡尼丁的概况为T1DM管理提供了洞察力.
- 之前的研究突出了T1DM中潜在的代谢变化,需要对儿科患者群体进行进一步的研究.
研究的目的:
- 评估与健康对照组相比,患有T1DM的埃及儿童的营养状况和代谢概况.
- 调查T1DM儿童的人类测量,血糖控制 (HbA1c%) 和特定氨基酸和肉丁水平之间的关系.
- 确定改变氨基酸和卡尼丁代谢对儿科T1DM生长和血糖控制的影响.
主要方法:
- 一项涉及100名埃及儿童 (50名T1DM,50名对照,年龄在6-18岁之间) 的病例控制研究.
- 通过身体质量指数 (BMI) Z-score评估营养状况.
- 扩展代谢查 (EMS) 使用高性能液体染色学-喷射电离-质谱学分析14种氨基酸,自由卡尼丁和27种卡尼丁.
主要成果:
- T1DM儿童的BMI Z-分数明显较低,营养不良占16%,矮身占32%.
- 在T1DM儿童中观察到总芳香氨基酸,氨酸,氨酸,氨酸,氨酸,白氨酸,单氨酸,自由氨酸和各种氨酸 Ester 的水平较低.
- 在BMI Z-score和几种氨基酸/卡尼丁之间,以及在HbA1c%和氨基酸/卡尼丁之间发现了显著的相关性,这表明代谢失调会影响血糖控制.
结论:
- 患有T1DM的儿童表现出氨基酸和卡尼丁代谢的改变,导致生长缺陷并可能影响血糖控制.
- 定期进行营养评估,包括扩展代谢查,对于优化儿科T1DM患者的饮食质量和蛋白质摄入量至关重要.
- 这些评估可以指导改善T1DM儿童生长和血糖管理的干预措施.
更多相关视频
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
06:59Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
