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Updated: Jun 13, 2025

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

Published on: April 24, 2020

开发一个完全自动化的工作站,用于执行常规的SABRE超极化.

Jing Yang¹, Ruodong Xin¹, Sören Lehmkuhl¹

¹Karlsruhe Institute of Technology (KIT), Institute of Microstructure Technology (IMT), 76344, Eggenstein-Leopoldshafen, Germany.

Scientific reports

|September 9, 2024

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Rapid RASER MRI.

Angewandte Chemie (International ed. in English)·2026

一个新的自动化工作站简化了用于核磁共振 (NMR) 的缓冲气交换 (SABRE) 超极化旋转放大. 该系统提高了可重现性和效率,使先进的NMR技术更容易获得研究.

科学领域:

核磁共振 (NMR) 光谱学核磁共振 (NMR) 光谱学
超极化技术超极化技术
化学仪器仪表化学仪器仪表

背景情况:

通过缓冲气体交换 (SABRE) 的旋转放大提供了一种快速,简单和低成本的方法来增强NMR信号.
手动执行SABRE导致可复制性和效率的不一致.
现有的自动化系统复杂,难以集成到标准的实验室工作流程中.

研究的目的:

为SABRE超极化开发一个全自动化实验室工作站.
为了促进SABRE对各种核和极化场的实验,使用基板NMR光谱仪.
克服手动SABRE和复杂的自动化系统的局限性.

主要方法:

构建一个完全自动化的实验室工作站,集成与台式NMR光谱仪.
对不同核 (例如,13C) 实施常规的SABRE实验协议.
极化转移场的优化,测量极化积聚率和各种磁场的衰变时间.
脉冲SABRE-SHEATH 13C酸盐持续时间的代优化.

主要成果:

在连续的SABRE超极化中显示出高可重现性 (平均标准偏差为1.03%).
成功优化了13C核对偏振转移场的偏振.

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相关实验视频

Last Updated: Jun 13, 2025

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

Published on: April 24, 2020

Optimization, Test and Diagnostics of Miniaturized Hall Thrusters

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Published on: February 16, 2019

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Published on: February 25, 2021

在广泛的磁场中表征着极化积聚率和衰变时间.

实现了脉冲SABRE-SHEATH 13C pyruvate的优化持续时间.

结论:

开发的SABRE工作站提供了完全的自动化,高可重复性和功能多功能性.
它作为常规SABRE超极化实验的实用工具.
该系统为高通量和可靠的SABRE和X-SABRE超极化研究提供了一个强大的平台.