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Updated: Jun 13, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

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用于卡瓦克罗尔激活OTOP1质子通道的门元件

Jingmei Hu1,2, Yalan Han1, Anna Luo1

  • 1Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan, China.

Communications biology
|September 9, 2024
PubMed
概括

卡瓦克罗尔激活了Otopetrin 1 (OTOP1) 通道,这对于酸味的感知至关重要. 跨膜段3和TM5-6链接器中的特定残留物是这种激活的关键,提供了潜在的药物设计目标.

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