相关实验视频

Updated: May 5, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

9个人类疹病毒包裹糖蛋白的免疫遗传特征

Apostolos P Georgopoulos^1,2,3, Lisa M James^4,5,6

¹The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis VAMC, One Veterans Drive, Minneapolis, MN, 55417, USA. omega@umn.edu.

Scientific reports

|September 9, 2024

概括

人类疹病毒 (HHV) 与人类白细胞抗原 (HLA) 基因结合的基因差异很大. 这种HHV-HLA相互作用的变化可能会影响病毒感染后的长期健康结果.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
遗传学是一个遗传学.

背景情况:

人类疹病毒 (HHV) 广泛存在,并与慢性健康问题有关.
人类白细胞抗原 (HLA) 基因变异影响病毒暴露对长期健康的影响.

研究的目的:

通过计算评估9个HHV包膜糖蛋白和127个常见的HLA I类和II类分子之间的结合亲和力.
了解HLA基因变异如何影响HHV结合和潜在的长期健康后果.

主要方法:

在HHV包膜糖蛋白和HLA分子之间的结合亲和关系的分析.
评估跨不同HLA类,基因和等位基因的结合.

主要成果:

结合HHV的亲缘关系分为四个不同的组,其中HHV1,HHV2和HHV6a的亲缘关系较低.
一类HLA的结合亲和力明显高于二类HLA的结合亲和力.
HLA-C (I类) 和HLA-DRB1 (II类) 等位基因表现出最高的结合亲缘关系.
总体来说,HHV6a具有最低的结合亲和力,而HHV3,HHV4和HHV5具有最高的结合亲和力.

结论:

在HHV-HLA结合亲缘关系中存在显著的变异性.
这些结合性差异可能会影响免疫反应的启动和HHV感染对长期健康影响的严重程度.
感染了具有较高HLA结合亲和度的病毒的细胞可能会减少,这可能会降低长期后果的风险.

关键词:

结合性亲缘关系是一种结合性亲缘关系.人类疹病毒人类疹病毒人类白细胞抗原 (HLA)

更多相关视频

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

Published on: August 31, 2017

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

Published on: January 15, 2020

相关概念视频

Retroviruses

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...

Human Virome

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...