在心力衰竭患者中,腹部肥胖与功能恶化的风险增加有关,心力衰竭患者具有保存的喷射分数
Quan Zhang1, Shi Tai1, Shenghua Zhou2
1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
BMC cardiovascular disorders
|September 9, 2024
概括
在心力衰竭患者中,腹部肥胖增加了功能恶化的风险 (WRF),其中包括心力衰竭患者的保存喷射分数 (HFpEF). 在这个人群中,腰围比体重指数更好地预测WRF.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肥胖医学 肥胖医学
背景情况:
- 恶化功能 (WRF) 是心力衰竭中常见的一种并发症,与保存的喷射分数 (HFpEF) 相关.
- 在HFpEF患者的腹部肥胖和WRF之间的特定关系尚不清楚.
- 本研究研究了HFpEF中WRF的腰围 (WC) 和体重指数 (BMI) 的预测值.
研究的目的:
- 为了评估WC和BMI在预测HFpEF患者的WRF.
- 为了检查腹部肥胖和HFpEF群体中WRF风险之间的相关性.
主要方法:
- 使用阿尔多激素对抗剂试验 (NCT00094302) 治疗心脏功能保护心力衰竭的数据.
- 定义的腹部肥胖是WC≥102厘米 (男性) 或≥88厘米 (女性). WRF被定义为血清肌素的翻倍.
- 采用受限立方线,ROC曲线,累积发病率曲线和Cox比例危险模型.
主要成果:
- 包括2,806名HFpEF患者;2,065人患有腹部肥胖.
- 患有腹部肥胖症的患者在40.9个月的中位随访期间表现出更高的肌素水平.
- 与BMI相比,WC是一个优越的WRF预测器,显示出线性关联. 腹部肥胖增加了WRF风险 (HR: 1.632; P: 0.043).
结论:
- 腹部肥胖与HFpEF中WRF风险增加显著相关.
- 腰围是预测WRF在这个患者群体中的一个有价值的工具.
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