在系统性审查或元分析中使用试验顺序分析的主要错误或错误 - - METSA系统性审查
Christian Gunge Riberholt1,2,3, Markus Harboe Olsen4,5, Joachim Birch Milan4
1Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark. christian.riberholt@regionh.dk.
系统性审查中的试验顺序分析 (TSA) 往往缺乏透明度,原因是协议不良. 这影响了元分析结果的可靠性和可重复性,阻碍了临床决策.
科学领域:
- 医学统计 医学统计
- 证据综合 证据综合
- 临床试验方法论 临床试验方法论
背景情况:
- 系统审查和元分析对于临床实践,研究和卫生政策至关重要.
- 试验顺序分析 (TSA) 是一种控制系统审查中的统计错误的方法.
- 有关方法错误和TSA报告缺乏透明度存在担忧.
研究的目的:
- 在系统性审查和元分析中评估试验顺序分析的报告质量和透明度.
- 在TSA的应用中识别常见的方法错误和遗漏.
主要方法:
- 对2018年1月至2021年12月期间发表的研究进行了Medline和Cochrane系统性评论数据库的系统搜索.
- 包括至少两项随机临床试验的系统审查/元分析,一个森林地块和一个TSA.
- 两个独立的调查人员评估了协议化,参数报告,解释和对GRADE的影响.
主要成果:
- 在270次系统审查中,只有50%的协议规划了TSA.
- 对于TSA的基本参数经常缺失,特别是连续结果 (例如,差异缺失78%).
- 图形插图的TSA是常见的 (93%),但Z曲线经常错误显示 (22%) 和徒劳的边界被遗漏在36%.
结论:
- 大多数试验序列分析在准备和呈现方面表现出不良的透明度.
- 缺失或不充分的协议在很大程度上导致了这些报告缺陷.
- 缺乏透明度阻碍了系统审查结果的解释,可复制性和有效性.
更多相关视频
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
相关概念视频
Systematic Error: Methodological and Sampling Errors
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
Errors In Hypothesis Tests
Accuracy and Errors in Hypothesis Testing
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5%...
Random and Systematic Errors
Bias
In statistics, a sampling bias is created when a sample is collected from a population, and some members of the population are not as likely to be chosen as others (remember, each member...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
