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在抗血管内皮生长因子治疗糖尿病黄斑的过程中,光学连贯性断层扫描对微动脉瘤进行血管造影

Tongmei Zhang¹, Shiyong Xie¹, Xiaoli Sun¹

¹Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, 4th Gansu Road, Heping District, Tianjin, 30020, PR China.

BMC ophthalmology

|September 9, 2024

概括

在接受抗血管内皮生长因子 (抗VEGF) 治疗的糖尿病黄斑 (DME) 患者的微动脉瘤 (MAs) 比非DME患者更大,血液流量更大. 在MA大小变化之前,治疗后中央黄斑厚度的改善.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
糖尿病视网膜病变糖尿病视网膜病变

背景情况:

糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
微动脉瘤 (MAs) 是DR的早期症状.
了解抗血管内皮生长因子 (抗VEGF) 治疗后的MA行为对于管理慢性胀和治疗耐药性至关重要.

研究的目的:

在抗VEGF治疗后对糖尿病视网膜病变患者的微动脉瘤 (MAs) 进行评估.
调查MA特征与糖尿病黄斑 (DME) 之间的关系.
探索导致慢性胀和抗VEGF治疗耐药性的因素.

主要方法:

光学连贯断层扫描血管造影 (OCTA) 用于评估43名患有非增殖性糖尿病视网膜病变的患者48只眼睛的MAs.
关键的OCTA参数包括MA最大直径,物质存在,流量信号,中央黄斑厚度 (CMT),状血管区和毛细血管的测量.
患者被分为糖尿病黄斑 (DME) 和非DME (NDME) 组.

主要成果:

与NDME组 (平均直径74.70微米) 相比,DME组在基线表现出显著更大的MA (平均直径99.40微米) (P <0.001).
在DME组中,较高比例的MAs显示出可测量的血液流动 (83.6%) 与NDME组 (59.3%) (P < 0.001).
在6个月的随访期间,DME和NDME组之间的中央黄斑厚度 (CMT) 在6个月的随访期间有显著差异 (P < 0.001).

结论:

与非糖尿病性斑点 (DME) 相比,糖尿病性斑点 (DME) 与较大的微动脉瘤 (MA) 和增加的血流信号有关.
在抗VEGF治疗后,MA直径的变化比中央黄斑厚度 (CMT) 的变化更早观察到.
这些发现凸显了MAs在DME病原和治疗反应中的作用.

关键词:

糖尿病性黄斑胀糖尿病性黄斑胀微动脉瘤 (MAs) 是一种小动脉瘤.非扩散性糖尿病视网膜病变有关OCT的血管学.血管内皮生长因子血管内皮生长因子

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