在艾滋病毒/艾滋病感染者中,与皮症相关的患病率和相关因素
Luciana Cardoso Martins1, Marcelo Palmares Oliveira E Silva2, Ana Célia Oliveira Dos Santos3
1Department of Tropical Medicine, Medical Sciences Center, Federal University of Pernambuco, Avenida Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, CEP: 50740-465, Brasil. lu_upe@hotmail.com.
BMC infectious diseases
|September 9, 2024
概括
在40岁以上的艾滋病毒/艾滋病感染者 (PLWHA) 中,麻症的患病率为8.7%. 在这个老龄化人口中,更长的HIV持续时间和非法药物使用与更高的肉症风险有关.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 肌肉骨健康 肌肉骨健康
背景情况:
- 抗逆转录病毒疗法增加了艾滋病毒/艾滋病感染者 (PLWHA) 的生存率,导致人口老龄化.
- 这种人口结构的转变与萨尔科佩尼亚的发病率上升有关,这种疾病的特征是肌肉质量和力量的损失.
- 报告的肉症患病率的变化强调了需要标准化诊断标准和本地研究的需要.
研究的目的:
- 为了确定40岁及以上艾滋病毒/艾滋病感染者 (PLWHA) 中的肉类的患病率.
- 通过使用欧洲老年人肉病工作组 (EWGSOP2) 修订的标准,在这个人群中识别与肉病相关的因素.
- 提供有关肉症患病率的当地数据,解决先前研究中的不一致性.
主要方法:
- 从2019年到2021年进行了一项横截面研究.
- 参与者包括218名40岁以上的PLWHA,他们在第三级医院的传染病诊所接受治疗.
- 使用EWGSOP2标准评估了萨尔科佩尼亚,包括尾肌肉量 (生物阻抗),肌肉强度 (动力学) 和步行速度.
主要成果:
- 在研究的PLWHA中,肉类的患病率为8.7% (95% CI:5.6至13.3).
- 参与者的平均年龄为51.8岁,53.7%是男性,72.9%是棕色/黑色.
- 多变量分析表明,自艾滋病毒诊断以来的更长时间 (P=0.022) 和非法药物使用显着与麻症相关.
结论:
- 根据EWGSOP2标准定义的麻症的患病率在这个PLWHA队列中相对较低.
- 具有较长艾滋病毒感染史的个人和使用非法药物的人更有可能患上肉症.
- 这些发现凸显了在评估老化PLWHA中的肉症风险时考虑疾病持续时间和物质使用的重要性.
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