结直肠癌的表观遗传学和免疫疗法:进展和承诺
Tianjiao Dang1,2,3, Xin Guan1,2,3, Luying Cui1,2,3
1Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150001, Heilongjiang, People's Republic of China.
Clinical epigenetics
|September 9, 2024
概括
新的结直肠癌 (CRC) 治疗方法正在出现. 将免疫疗法与表观遗传疗法结合起来,对于微卫星稳定的CRC患者,这些患者对当前的治疗没有反应,显示出有前途.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症发病率和死亡率的主要原因.
- 目前的疗法,包括免疫疗法,对于具有熟练的不匹配修复/微观卫星稳定性的显著CRC患者小组是无效的.
- 对于这些不响应的CRC病例,迫切需要新的治疗策略.
研究的目的:
- 审查表观遗传调节在调节抗瘤免疫反应中的作用.
- 确定潜在的表观遗传基因标记物,用于预测CRC中免疫疗法的疗效.
- 探索表观遗传疗法和免疫疗法的结合,作为治疗CRC的新策略.
主要方法:
- 关于结直肠癌表观遗传学和免疫治疗的临床前和临床研究的文献综述.
- 对影响瘤微环境中的免疫细胞功能表观遗传机制的分析.
- 对表观遗传药物敏感化策略的评估,以增强免疫疗法反应.
主要成果:
- 表观遗传修饰在调节免疫细胞活性和抗瘤作用方面发挥着至关重要的作用.
- 特定的表观遗传基因显示出CRC中免疫治疗反应的预测生物标志物的潜力.
- 将表观遗传剂与免疫疗法结合起来,可以克服耐药性并改善治疗结果.
结论:
- 表观遗传疗法具有显著的潜力,可以提高结直肠癌免疫疗法的疗效.
- 向表观遗传机制为开发抗免疫疗法抗性CRC的新型治疗策略提供了一个有希望的途径.
- 对表观遗传生物标志物和组合疗法的进一步研究是有必要的,以改善患者的治疗结果.
相关概念视频
01:27Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:30Cancer Vaccines
345
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
345