自主功能障碍作为ICANS的表现:一个案例报告
Dina Rochate1, Antonio Manuel González-García2, Carmen Santos Marcos3
1Hematology Department, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal.
Medicine
|September 10, 2024
概括
抗CD19CAR-T疗法可以导致自主功能障碍,一种类型的免疫效应细胞相关神经毒性综合征 (ICANS). 早期识别和治疗这种情况对于患者的康复至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 抗CD19的CAR-T疗法对B细胞恶性瘤有效.
- 细胞因子释放综合征 (CRS) 和ICANS是已知的副作用.
- 报告了心血管毒性,但自主性障碍的理解较少.
研究的目的:
- 在CAR-T治疗后报告一个自主功能障碍病例.
- 突出自主功能障碍作为ICANS的潜在表现.
主要方法:
- 一名患有耐火性非霍奇金B细胞淋巴瘤的患者接受了CAR-T治疗.
- 由于自主功能障碍导致的正静性低血压被诊断为ICANS.
- 治疗包括甲基prednisolone和anakinra.
主要成果:
- 患者经历了自主症状的消失.
- 自主功能障碍在CAR-T治疗后4个月内得到解决.
结论:
- 新出现的自主功能障碍可以在CAR-T治疗后表现为ICANS.
- 早期识别持续的神经和心血管症状至关重要.
- 这一案例强调了需要意识到自主性复杂症后CAR-T.
相关概念视频
Disorders of the Autonomic Nervous System
588
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
588
Irritable Bowel Syndrome I: Introduction
257
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
257
Irritable Bowel Syndrome III: Medical and Nursing Management
180
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
180
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
147
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
147
Autonomic Nervous System: Overview
3.9K
The human nervous system is divided into two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and spinal cord, while the PNS contains nerve cells, clusters of nerve cells, and the sensory receptors that are outside the CNS. The PNS has two types of nerve cells: sensory (afferent) and motor (efferent). Sensory cells send signals to the CNS from receptors, and motor cells carry signals from the CNS to organs, muscles, and...
3.9K
Autonomic Nervous System
8.6K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
8.6K


