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拉姆诺斯消费对健康绝经后妇女骨矿物质密度的影响:一项随机,安慰剂控制,双盲,并行组试点研究
Naoko Suzuki1, Takafumi Imada2, Naoki Ueshima2
1R&D Department, ORTHOMEDICO Inc, Tokyo, Japan.
International journal of food sciences and nutrition
|September 10, 2024
概括
补充Rhamnose可能有助于绝经后妇女保持骨矿物质密度 (BMD). 这项研究发现,每天1.0克拉姆诺斯显著增加腰椎骨质量,减少骨复吸标志物.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 绝经后的骨质疏松症是一个重大的健康问题,其特点是骨矿物质密度 (BMD) 降低.
- 拉姆诺斯是一种脱氧单糖和食品添加剂,已经显示出抑制骨再吸收的潜力.
- 临床证据支持rhamnose在绝经后妇女的BMD维护疗效是有限的.
研究的目的:
- 为了研究拉姆诺斯补充剂对绝经后妇女的骨硬度的影响.
- 为了确定拉姆诺斯能否抑制这个人群中的骨质再吸收标记物.
- 提供关于rhamnose在绝经后维持骨健康的初步数据.
主要方法:
- 一项为期24周的试点研究,涉及绝经后妇女.
- 参与者每天服用1.0g或0.5g的拉姆诺斯,或安慰剂.
- 测量包括骨矿物质密度 (腰椎,大腿骨) 和骨周转标志物.
主要成果:
- 与安慰剂组相比,接受每天1.0克拉姆诺斯的小组显示腰椎骨髓 BMD 显著更高.
- 两组拉姆诺斯都表现出明显较低的酸盐耐药酸酸酶5b水平,这是骨再吸收的关键标志物.
- 这些发现表明,拉姆诺斯在减轻骨质损失方面可能发挥作用.
结论:
- 补充Rhamnose,特别是每天1.0g,可能有助于维持健康的绝经后妇女的BMD.
- 拉姆诺斯似乎通过抑制骨再吸收来发挥作用.
- 需要进一步的研究来证实这些发现并确定最佳剂量.
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