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在创伤质量改进计划注册表中,描述了人类衍生的冷凝凝固度的实践模式

Chester A Rosenthal¹, David J Douin¹, Mitch J Cohen²

¹Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Transfusion medicine (Oxford, England)

|September 10, 2024

概括

在创伤患者中使用前热血素复合缩剂 (PCC) 和纤维原缩剂 (FC) 是不常见的,但在PCC中使用越来越多. 大多数PCC的使用是用于头部创伤的抗凝固逆转,突出显示需要更多数据.

科学领域:

创伤和紧急医疗医学
血液学血液学血液学
药理学药理学是指药理学的学科.

背景情况:

创伤诱导的凝血病 (TIC) 和创伤的内皮病 (EOT) 在创伤性出血患者中显著增加死亡率.
纤维素缩物 (FC) 和4因子原复合物缩物 (PCC) 分别是EOT和TIC的潜在治疗剂.

研究的目的:

描述当前在创伤患者中使用前热血素复合缩物 (PCC) 和纤维素原缩物 (FC) 的实践模式.
分析创伤护理机构中PCC和FC的管理趋势.

主要方法:

数据是从创伤质量改善计划 (TQIP) 注册表中提取的.
使用程序代码识别了接受PCC或FC的患者.
用描述性统计数据来描述产品使用模式.

主要成果:

在2017年至2022年期间,在6,714,002次总体接触中,有10,589名患者接受PCC和3,009人接受FC.
观察到使用PCC的设施数量呈上升趋势,而使用FC的设施数量呈轻微下降趋势.
PCC主要用于逆转抗凝血,特别是在头部创伤的情况下.

结论:

在创伤患者中,PCC和FC的使用仍然很少,尽管PCC的使用正在增加.
目前的PCC应用主要涉及头部创伤患者的抗凝固逆转.
进一步的研究和数据对于指导PCC和FC作为治疗创伤性出血的辅助剂的最佳使用至关重要.

关键词:

凝血病是一种凝血病.复杂的复杂的复杂的复杂的复杂.这是一种缩缩剂.纤维素原体是有纤维的发生出血发生出血在这种情况下,前血 (prothrombin) 会被转化为血.创伤的创伤创伤的创伤.

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