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Updated: Jun 13, 2025

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脊髓损伤引起的神经病痛的脊髓损伤引起的脊髓外水道灰色连接
Omid Shoraka1, Mashaal Syed1, Shreya Mandloi1
1Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
概括
脊髓损伤 (SCI) 后的神经病痛与周水道灰色 (PAG) 中的功能连接 (FC) 变化有关. 这些大脑网络的变化突出了治疗SCI相关疼痛的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 功能神经成像 功能神经成像
- 疼痛研究 疼痛研究
背景情况:
- 神经病痛 (NP) 是脊髓损伤 (SCI) 后的一个显著并发症.
- 在SCI后NP的发展中,近水管灰色 (PAG) 的作用尚不清楚.
- 休息状态功能性MRI (rsfMRI) 提供了一种研究大脑连接的方法.
研究的目的:
- 在SCI和NP的个体中研究PAG的功能连接 (FC) 的变化.
- 为了比较患有SCI和NP的患者,没有NP的SCI患者和健康对照 (HC) 之间的FC模式.
主要方法:
- 从10名SCI患者 (7名有NP,3名没有NP) 和10名HC患者获得了rsfMRI扫描.
- 用PAG作为种子区域进行了种子到素分析.
- 进行了基于组的分析,对年龄和性别进行了控制.
主要成果:
- 与HCs相比,患有NP的SCI患者在PAG和区域之间显示了降低的FC,包括右侧胰岛,额外轨道皮质,皮,背侧核 (DRN),红核 (RN),黑质体 (SN) 和腹后侧 (VPL) 体.
- 与没有NP的SCI患者相比,NP患者在PAG和后带皮质 (PCC),海马和小脑之间增加了FC,以及与thalamic核的连接性发生了变化.
- 在带有NP的SCI患者和没有NP的SCI患者中,PAG和VPL丘脑,DRN,RN,SN和前额皮层之间的CF降低也被注意到.
结论:
- 在SCI之后,PAG与胰岛,VPL丘脑,DRN,RN,SN,小脑,前皮层和PCC的改变FC与神经病痛有关.
- SCI本身独立地与PAG与后面岛屿和特定小脑区域的连接性降低有关.
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