围产期肥胖性环境与后代生物衰老的长期关联
Ilona Shapiro1, Iaroslav Youssim1, Salomon Israel1
1Braun School of Public Health, Hebrew University of Jerusalem, Jerusalem, Israel Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.
American journal of epidemiology
|September 10, 2024
概括
怀孕期间母亲的身体大小会影响后代的生物年龄 (BA),这是一种超越时间年龄的衰老指标. 针对青少年和年轻人的体重管理可能会促进更健康的衰老路径.
科学领域:
- 老年学是一门学科.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 生物年龄 (BA) 反映了超越时间年龄的健康状况下降,并且因人而异.
- 孕产妇的体型 (孕前BMI,孕期体重增加) 与后代的健康有关,但其对年轻成人BA的影响还未得到充分研究.
- 了解这些联系可以揭示代际健康机制,并告知干预措施.
研究的目的:
- 为了研究母亲的孕前体重指数 (BMI) 和孕期体重增加 (GWG) 与32岁后代的生物年龄 (BA) 之间的关联.
- 探索这些关联的潜在家庭生命过程机制,包括后代的BMI轨迹和母亲的心脏代谢健康.
- 确定促进健康衰老的潜在干预点.
主要方法:
- 来自耶路撒冷周产期研究的1148对母子对的纵向分析.
- 后代的生物年龄 (BA) 在32岁时使用Klemera-Doubal方法 (KDM) 进行评估.
- 统计模型根据社会人口统计学,生活方式因素,BMI的后代多基因风险评分和母亲心脏代谢状况进行调整.
主要成果:
- 孕前母亲的BMI和GWG与更高的后代BA显著相关,即使经过对混因素进行调整.
- GWG与BA的关联在很大程度上是直接的,而孕前母亲的BMI的影响部分是由青少年后代的BMI介导的.
- 这些关联在调整后代多基因BMI风险得分后仍然存在,并且因母亲的心脏代谢状况而有所改变.
结论:
- 产后肥胖的环境,受到母亲的体型的影响,导致后代的生物年龄独立于社会人口统计学因素和母亲的健康史.
- 肥胖的代际传播似乎是将母体体型与后代的关键机制之一.
- 针对青春期和年轻成年期体重管理的干预措施可能对于减轻对健康衰老的长期影响至关重要.
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