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长期COVID在艾滋病毒感染者中:系统性审查和元分析

Xueying Yang^1,2,3, Fanghui Shi^1,2,3, Hao Zhang⁴

¹Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

|September 10, 2024

概括

由于免疫问题,艾滋病毒感染者患长期COVID (LC) 的风险更高. 这项审查发现,52%的艾滋病毒感染者经历了LC,这突显了针对性预防策略的需要.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

艾滋病毒 (人类免疫缺陷病毒) 感染者可能因免疫功能障碍和慢性炎症而面临长期COVID (LC) 风险增加.
对SARS-CoV-2 (严重急性呼吸道综合征冠状病毒-2) 感染的免疫反应的改变有助于增加这种脆弱性.

研究的目的:

系统地审查艾滋病毒感染和LC之间的联系.
确定艾滋病毒感染者中LC的患病率,特征和危险因素.

主要方法:

对2023年6月之前发表的文章进行了多个数据库 (Embase,PubMed,PsycINFO,Web of Science,社会学摘要) 的系统审查.
包括涉及艾滋病毒感染者的研究,并报告了至少一种使用定量或混合方法设计的LC结果测量.
使用随机效应模型进行了对三项或更多研究报告的效应的元分析.

主要成果:

该审查分析了17项涉及39405名艾滋病毒和COVID-19感染者的研究.
据估计,52%感染SARS-CoV-2的HIV感染者至少有一种LC症状.
艾滋病毒感染与LC的风险增加了2.20倍 (95% CI 1.25-3.86). 常见的症状包括咳,疲劳和喘息. 确定的危险因素包括中度至重度的COVID-19,炎症标志物 (IFN-γ,TNF-α) 的升高以及IFN-β的降低.

结论:

由于LC风险较高,COVID-19大流行加剧了艾滋病毒感染者的健康不平等.
这些发现对于公共卫生和临床专业人员来说至关重要,以制定针对性策略,在这个人群中预防和管理LC.

关键词:

艾滋病毒/艾滋病病毒/艾滋病病毒长时间的COVID.这是一个元分析.系统性审查系统性审查

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