在有或没有SARS-CoV-2感染 (PASC) 后急性后果患者的病毒,免疫学和实验室参数
Sang Hyun Ra1, Euijin Chang1, Ji-Soo Kwon1
1Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Journal of Korean medical science
|September 10, 2024
概括
COVID-19 (PASC) 后急性后续包括病毒核蛋白和与免疫相关的细胞因子的升高. 这些发现表明,由于持续的抗原刺激,PASC患者的免疫失调持续了很长时间.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸系统综合征冠状病毒2型感染 (PASC) 后急性后续症状的机制尚不清楚.
- 在PASC患者中调查病毒持久性,免疫反应和实验室标记是非常重要的.
研究的目的:
- 探索PASC的病理生理机制.
- 为了比较患有和没有PASC的患者之间的病毒持久性和免疫学概况.
主要方法:
- 对被诊断患有COVID-19的成年人进行潜在的招生.
- 在急性期,诊断后1个月和3个月收集血液样本.
- 基于验证的问卷得分 (≥12) 持续至少4周的PASC的定义.
主要成果:
- 在51%的患者中存在PASC.
- 在PASC组3个月后观察到核蛋白 (NP) 抗原血症的升高 (P=0.022).
- 在1个月和/或3个月的PASC组中增加了细胞因子 (IL-2,IL-17A,VEGF,RANTES,sCD40L,IP-10,I-TAC,大酶A) 的水平.
结论:
- 在COVID-19后的时间里,PASC与NP抗原和免疫细胞因子的升高有关.
- 表明PASC涉及由于抗原刺激升高而引起的长期免疫失调.
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