患有血液性恶性瘤的患者的前中性热:抗菌药物管理的新目标
Jessica Chiodo-Reidy1, Monica A Slavin1,2,3,4,5, Shio Yen Tio1,2,3,4
1Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Open forum infectious diseases
|September 10, 2024
概括
血性恶性瘤患者中常见的是前性发烧 (PNF),但感染很罕见. 在PNF后早期停止经验性抗微生物治疗可能是一个重要的抗微生物管理干预措施.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 在接受化疗或调节治疗的血液性恶性瘤患者中,发烧很常见.
- 预中性发烧 (PNF) 的传染病因是不确定的.
- 在化疗诱导的中性质减退之前发生PNF.
研究的目的:
- 为了确定PNF与传染病因的比例.
- 检查PNF患者的抗微生物治疗使用情况.
- 为抗菌药物管理干预提供信息.
主要方法:
- 在接受AML化疗或allo-HCT调节的成年人中对PNF进行前性观察性副研究.
- 包括中性粒细胞>0.5细胞/μL和发烧 (≥38.0°C) 的患者.
- 确定了感染,并分析了抗菌药物治疗模式.
主要成果:
- 44%的患者患有PNF.
- 只有19%的PNF病例具有已确定的感染原因.
- 患有PNF的患者更有可能接受升级式抗菌素治疗.
结论:
- PNF是常见的,但记录的感染很少发生.
- 长期和升级的抗微生物治疗在PNF中很常见.
- 建议在没有感染的情况下早期停止实证治疗,以确保抗微生物药物管理.
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