静脉血栓栓塞的高风险是什么? 比较确定适当门的方法
Benjamin G Mittman1,2, Bo Hu3, Rebecca Schulte3
1Center for Value-Based Care Research, Community Care, Cleveland Clinic, Cleveland, OH, USA.
medRxiv : the preprint server for health sciences
|September 10, 2024
概括
确定静脉血栓塞栓症 (VTE) 预防的适当概率值至关重要. 这项研究表明,最优的VTE风险值约为0.5%,突出显示了减少医疗住院患者不必要预防的机会.
科学领域:
- 内部医学 内部医学
- 临床药理学 临床药理学
- 流行病学 流行病学
背景情况:
- 目前的指导方针建议对高风险患者进行药理性静脉血栓栓塞 (VTE) 预防,但缺乏风险分层的定义概率值.
- 这种模两可导致医疗住院患者的预防决策变化.
研究的目的:
- 确定适当的VTE风险分层和医疗住院患者相应预防的概率值.
- 为了比较确定这一门的不同方法.
主要方法:
- 分析了10家医院41036名成年住院患者的队列.
- 用五种不同的方法来确定VTE风险概率值,包括决策分析,后勤回归,以点为基础的模型和医生调查/行为分析.
- 克利夫兰诊所VTE风险评估模型 (CCM) 应用于使用衍生值的队列.
主要成果:
- 分析的方法产生了从0.3%到5.4%的VTE风险值.
- 多种方法汇聚在0.52%和0.55%之间的值集群中,这表明假设的预防率约为30%.
- 医生观察到的预防率 (48%-76%) 显著超过了这一建议率,表明过度治疗的可能性.
结论:
- 在医疗住院患者中,VTE预防的最佳概率值约为0.5%.
- 当前的临床实践涉及比这个门所指出的更频繁的预防,这表明需要优化.
- 准则应明确量化高风险VTE概率,以规范预防决策并减少不必要的治疗.
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
124
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
124
Pre-Procedural Guidelines for Assessing Blood Pressure
525
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
525
Venous Return
3.3K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
3.3K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
652
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
652


