没有证据表明,视网醇对皮肤癌有保护作用
Marloes Helder1,2, Nirmala Pandeya3,4, Mathias Seviiri2,5,6
1Division of Human Nutrition and Health, Wageningen University, the Netherlands.
medRxiv : the preprint server for health sciences
|September 10, 2024
概括
这项研究调查了维生素A (视网醇) 水平与皮肤癌风险之间的因果关系. 门德尔的随机化分析发现,遗传预测的视网醇水平与黑色素瘤,状细胞癌或基底细胞癌的发展之间没有显著的关联.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 遗传学 遗传学 是一个
背景情况:
- 皮肤癌,包括黑色素瘤和角质细胞癌 (KC),在全球普遍存在,每年新发病例超过150万.
- 乙醇是一种维生素A衍生物,在表皮细胞调节中起作用,并提供抗氧化剂保护,防止紫外线损伤.
- 之前关于视网醇对皮肤癌风险的影响的研究产生了相互矛盾的结果,需要进一步调查潜在的因果关系.
研究的目的:
- 调查循环中的视网醇水平与患黑色素瘤,状细胞癌 (SCC) 和基底细胞癌 (BCC) 的风险之间的潜在因果关系.
- 利用孟德尔随机化 (MR) 与全基因组关联研究 (GWAS) 数据来评估这种关联,克服观察性研究的局限性.
主要方法:
- 采用双样本的门德尔随机化 (MR) 方法,使用来自大型GWAS元分析 (INTERVAL和METSIM队列) 的网膜醇水平相关的遗传变异.
- 作为结果数据,利用了来自黑色素瘤,SCC和BCC的大规模GWAS元分析的总结统计数据.
- 使用单个遗传仪器 (SNP rs10882283,与RBP4相关) 和与视网醇水平相关的多个独立遗传变异进行了MR分析.
主要成果:
- 单种仪器和多种仪器的MR方法都没有显示出基因预测的视网膜醇水平与黑色素瘤风险之间的统计学意义上的关联.
- 同样,在任何MR分析中,没有发现视网膜醇水平与发展平细胞癌 (SCC) 或基底细胞癌 (BCC) 的风险之间存在显著的因果关系.
- 所有皮肤癌类型的几率比率保持在1.0附近,置信区间宽,表明网醇对皮肤癌发病缺乏明显的因果关系.
结论:
- 该研究没有发现证据来支持循环中的视网醇水平与患黑色素瘤,SCC或BCC的风险之间的因果关系.
- 这些发现表明,旨在改变循环中的视网醇水平的干预措施可能不是预防这些常见皮肤癌的有效策略.
- 进一步的研究可以探索其他维生素A代谢物或皮肤癌发展的不同病因因素.
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