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血液流量的定量全身成像,具有高时间分辨率早期动态 F-氧糖 PET 动态建模

Kevin J Chung¹, Abhijit J Chaudhari¹, Lorenzo Nardo¹

¹Department of Radiology, University of California Davis Health, Sacramento, CA.

medRxiv : the preprint server for health sciences

|September 10, 2024

概括

这项研究引入了一种早期动态的18F-氧葡萄糖 (FDG) PET方法,用于全身血流成像. 这种新的方法可以使用广泛可用的放射追踪器准确量化血液流量,克服了以前方法的局限性.

科学领域:

核医学就是核医学.
生理学生理学生理学
医疗成像医学成像

背景情况:

量化全身血流成像传统上依赖于短寿命的循环仪产生的标记物,如15O-水或11C-butanol.
之前使用18F-氧葡萄糖 (FDG) 的尝试仅限于高提取分数的组织.
对于更广泛的临床和研究应用而言,对于血液流量评估而言,广泛使用的放射性追踪器的需求至关重要.

研究的目的:

开发和验证一种早期动态的18F-FDG PET方法,用于定量全身血流成像.
通过使用高时间分辨率动态建模,通过推导18F-FDG的血管运输时间来评估血液流动.
在试点研究中,将新型18F-FDG方法与参考标记物 (11C-butanol) 进行比较.

主要方法:

利用动态PET扫描的前两分钟的高时间分辨率 (1-2秒) 重建.
采用分布式运动模型 (adiabatic与组织同质性模型的近似;AATH) 来直接估计血液流量.
通过分析18F-FDG和11C-butanol扫描的人体参与者的全身动态PET扫描来验证该方法,并与文献值进行比较.

主要成果:

在18F-FDG衍生的血液流量和11C-布坦醇测量之间证明了定量一致 (皮尔森R=0.955,p<0.001).
参数成像视觉证实了整个身体的区域血流估计.
该方法准确地解决了健康参与者的广泛的生理血流值,与文献一致.

结论:

全身血流成像是可行的,使用早期动态的18F-FDG PET与高时间分辨率的动态建模.
这种方法促进了血液流动和新陈代谢的高效单个标志物成像.
在瘤学,心血管疾病,疼痛医学和神经科学方面具有重大研究和临床影响的潜力.

关键词:

血液流动/输血成像成像技术分布式运动建模分布式运动建模高时间分辨率的动态成像.整体体质的PET-PET.标记器动态建模标记器动态建模

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