在TyG指数和COPD之间的关联中探索性别差异:从NHANES1999-2018进行的跨部门研究
Jun Guo1, Jie Yang2, Jinghua Wang3
1General Surgery, Bethune International Peace Hospital, Shijiazhuang, People's Republic of China.
三甘-葡萄糖 (TyG) 指数与非糖尿病女性的慢性阻塞性肺病 (COPD) 有关,但与非糖尿病男性无关. 这突显了代谢健康和COPD风险之间的性别相关性.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 肺部医学 肺部医学
- 流行病学 流行病学
背景情况:
- 三甘油-葡萄糖 (TyG) 指数是胰岛素耐药性的标志物.
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题.
- 了解COPD的风险因素,尤其是非糖尿病人的风险因素,至关重要.
研究的目的:
- 调查TyG指数与COPD患病率之间的性别差异.
- 专门研究非糖尿病人群中的这种关系.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) (1999-2018) 的数据.
- 包括一个由23456名参与者组成的队列.
- 采用后勤回归和受限立方线分析.
主要成果:
- 在非糖尿病女性中,TyG指数和COPD患病率之间发现了显著的积极关联 (OR=1.50;95% CI,1.08-2.08).
- 没有观察到TyG指数与非糖尿病男性中COPD患病率之间的显著关联.
- 泰格指数没有显示出与糖尿病人群中COPD患病率的显著关联,不论性别.
结论:
- 泰格指数与非糖尿病人中COPD患病率呈正相关.
- 这种关联表现出显著的性别差异,存在于女性,但不存在于男性.
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