血清中CTRP3水平降低与结缔组织疾病有关
Lisha Ma1, Jiangbo Lin2, Miaoli Shao1
1Department of Clinical Laboratory, The First People's Hospital of Wenling, Affiliated to Wenzhou Medical University, Taizhou, Zhejiang Province, China.
Heliyon
|September 10, 2024
概括
在患有类风湿性关节炎,狼,Sjogren的患者中,CTRP3的血清水平明显较低.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 补充C1q瘤坏死因子相关蛋白3 (CTRP3) 和9 (CTRP9) 是具有多种生物功能的皮蛋白.
- 它们与结缔组织疾病 (CTD) 的关联在很大程度上仍未得到研究.
研究的目的:
- 调查血清中CTRP3和CTRP9水平与各种结缔组织疾病之间的关联.
- 评估CTRP3作为这些疾病的潜在诊断标志物.
主要方法:
- 使用ELISA测量了血清中CTRP3和CTRP9水平,这些患者患有类风湿性关节炎 (RA),全身性红斑狼 (SLE),原发性Sjogren综合征 (pSS),结性脊髓炎 (AS) 和不分化的结缔组织疾病 (UCTD),与健康对照者 (HCs) 相比.
- 进行了统计分析,包括多变量逻辑回归和ROC曲线分析.
主要成果:
- 与HC相比,RA,SLE,pSS和AS患者的血清CTRP3水平明显较低.
- 在患者组和HC之间没有观察到血清CTRP9水平的显著差异.
- CTRP3显示出作为RA,SLE,pSS和AS的诊断标记物的潜力,AUC值从0.658到0.727.7不等.
结论:
- 血清中CTRP3水平降低与类风湿性关节炎,全身性红斑狼,原发性Sjogren综合征和结性脊髓炎有关.
- CTRP3可以作为这些结缔组织疾病的潜在生物标志物.
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