灵长类动物和动物中促炎性囊的进化动态
Mische Holland1, Rachel Rutkowski1, Tera C Levin1
1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
bioRxiv : the preprint server for biology
|September 10, 2024
概括
进化分析揭示了灵长类动物和动物中炎症性卡斯帕斯的独特轨迹. 这些差异,特别是在caspase-1和caspase-5中,可能解释了人类和动物研究中的差异.
科学领域:
- 进化生物学是进化的生物学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 卡斯巴酶-1和相关蛋白酶对炎症和天生的免疫非常重要.
- 了解这些的进化历史对于解释人类疾病中的动物模型研究至关重要.
研究的目的:
- 描述caspase-1及其在灵长类动物和动物中的亲属的进化历史.
- 识别可能解释人类和动物研究结果之间的差异的进化差异.
主要方法:
- 对19种灵长类动物和21种动物中卡斯帕斯基因的比较基因组分析.
- 鉴定基因重复,损失,伪基因化和积极选择事件.
主要成果:
- 在所有研究的种群中,Caspase-1 存在.
- 在灵长类动物的caspase-5,caspase-11和CARD基因中观察到显著的基因损失和伪基因化事件.
- 卡斯帕-4和-11,在炎症酶通路中的关键,在很大程度上是保存的,而卡斯帕-5和灵长类卡斯帕-1显示了积极选择的迹象.
- 卡斯巴-12在人类和大多数灵长类动物中是一种伪基因,但在许多动物中具有功能.
- 动物的caspase-11和-12表现出特定菌株的变异影响功能.
- 灵长类卡斯帕斯通过基因转换,重复和损失显示出动态进化,与动物不同.
结论:
- 灵长类动物和动物的炎症性卡斯帕斯谱已经明显演变.
- 这些进化差异对的功能作用和动物模型的解释有影响.
- 对于caspase-11和-12研究,应仔细选择特定的动物菌株.
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