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Updated: Jun 13, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Published on: February 10, 2023

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断裂诱导的复制驱动癌细胞中的大规模基因组放大

Mouadh Benamar, Rebeka Eki, Kang-Ping Du

    bioRxiv : the preprint server for biology
    |September 10, 2024
    PubMed
    概括

    DNA双链断裂 (DSBs) 在癌细胞中诱导大规模基因组放大 (DIGA),导致细胞死亡. 这一过程由破坏诱导的复制介导,当DNA修复因子耗尽时,这种过程会得到增强.

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