常见的DNA序列变异影响非洲人口的表观遗传衰老
Gillian L Meeks1, Brooke Scelza2, Hana M Asnake3
1Integrative Genetics and Genomics Graduate Program, University of California, Davis, CA 95694, USA.
表观遗传年龄预测模型显示,由于DNA序列变异,未经研究的人口中错误率更高. 一个新的模型,考虑到甲基化定量特征位点 (meQTL),在各种遗传背景中保持了准确性,并表明遗传因素影响长寿.
科学领域:
- 遗传学 是一个遗传学.
- 基因组学就是基因组学.
- 衰老研究研究 衰老研究
背景情况:
- 衰老与全基因组DNA甲基化变化有关,使表观遗传年龄预测成为可能.
- 现有的表观遗传年龄预测器主要训练在欧洲祖先的个体上,并且不考虑甲基化定量特征位点 (meQTL).
研究的目的:
- 评估未经研究的非洲人群中的表观遗传年龄预测准确性.
- 开发一种新型的表观遗传年龄预测器,该预测器对遗传变异和meQTL效应具有稳定性.
- 探索遗传学,表观遗传衰老和长寿之间的关系.
主要方法:
- 分析巴卡,‡科马尼圣人和希姆巴人群的年龄,基因型和CpG甲基化.
- 在这些群体中评估现有的表观遗传年龄预测方法.
- 开发一个新的年龄预测器,结合meQTL信息.
- 研究与表观遗传衰老加速和寿命相关的遗传变异.
主要成果:
- 发表的表观遗传年龄预测器在研究的非洲群体中,与欧洲祖先的个人相比,表现出更高的平均误差.
- 未计数的DNA序列变异被确定为降低预测准确性的关键因素.
- 新开发的meQTL知情年龄预测器在各种基因背景中表现出一致的准确性.
- 老年人和表观遗传年龄加速较低的人携带了更多的表观遗传年龄减小遗传变异.
结论:
- 表观遗传年龄预测需要模型,这些模型可以考虑特定人群的遗传变异和meQTLs.
- 开发了一种新的,基因上强大的表观遗传年龄预测器.
- 可遗传的遗传因素可能会通过调节表观遗传衰老来影响寿命.
更多相关视频
13:47Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
Published on: March 29, 2019
11:08Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
Published on: October 16, 2014
相关概念视频
Epigenetic Regulation
X-chromosome...
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Multi-species Conserved Sequences
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
