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Updated: Jun 13, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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从基于形状的片段合并和主动学习来广泛探索SARS-CoV-2宏观域的结构活动关系

Galen J Correy1, Moira Rachman2, Takaya Togo2

  • 1Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158.

bioRxiv : the preprint server for biology
|September 10, 2024
PubMed
概括

研究人员开发了虚拟查工具FrankenROCS,以发现新型的SARS-CoV-2巨原体抑制剂. 这种方法确定了有前途的药物,可以改善病毒抑制疗法的膜透性.

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Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Mechanisms of Membrane Domain Formation

Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
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Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
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