2型糖尿病中血管放松受损:系统性审查和元分析
Sajad Jeddi1, Zahra Bahadoran2, Parvin Mirmiran2
1Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
EXCLI journal
|September 10, 2024
概括
2型糖尿病会影响血管平滑肌肉的放松. 无论是内皮依赖的还是内皮独立的通路都受到影响,在2型糖尿病患者中增加心血管风险.
科学领域:
- 心血管研究研究心血管研究
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 2型糖尿病 (T2D) 是血管并发症和死亡的一个重要风险因素.
- 在T2D中,内皮细胞 (ET) 和血管光滑肌 (VSM) 细胞的功能受损有助于心血管疾病.
- 了解VSM放松功能障碍对于管理T2D相关的血管问题至关重要.
研究的目的:
- 系统地审查和对T2D对内皮依赖和独立VSM放松的影响进行元分析.
- 量化T2D患者VSM放松通路损伤的程度.
主要方法:
- 在PubMed和Scopus数据库中进行系统的文献搜索,截至2024年3月.
- 包括44个符合条件的临床试验研究.
- 对乙胆 (ACh),甲胆 (MTH),酸 (SNP) 和甘三酸盐 (GTN) 的VSM放松反应的元分析.
主要成果:
- 在T2D患者中,ET-依赖放松 (到ACH和MTH) 和ET-独立放松 (到SNP和GTN) 都显著下降.
- 总体而言,依赖ET放松的总体减少约为40%,依赖ET放松的总体减少约为25%.
- 与ACh (~30%) 和SNP (~17%) 相比,MTH (~55%) 和GTN (~63%) 的损伤更为明显.
结论:
- T2D与ET依赖和ET独立VSM放松的显著损害有关.
- 随着ET功能障碍,VSM细胞功能障碍与ET功能障碍一起,导致T2D的血管并发症.
- 这些发现凸显了T2D中广泛存在的血管功能障碍,影响了光滑肌肉的反应能力.
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