富含纤维的饮食会减少骨的形成,但不会影响2型糖尿病患者的骨微型结构
Malak Faraj1, Giulia Leanza1, Johannes Krug2
1Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
JBMR plus
|September 10, 2024
概括
富含纤维的饮食改善了血糖控制,并降低了2型糖尿病患者的BMI. 然而,这种饮食干预可能会降低骨形成标记物,而不会影响骨结构.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 骨生物学 骨生物学 骨生物学
背景情况:
- 2型糖尿病 (T2DM) 与骨脆弱性和发病率的增加有关.
- 生活方式干预对于T2DM管理至关重要,并可能影响骨健康.
- 食纤维对T2DM患者骨健康的具体影响尚不清楚.
研究的目的:
- 研究高纤维饮食对T2DM患者骨健康和葡萄糖控制的影响.
- 评估骨形成和再吸收标记,骨微观结构和相关基因表达的变化.
- 确定食纤维干预是否影响T2DM中的代谢参数和骨代谢.
主要方法:
- 一项随机对照试验,涉及45名T2DM患者,计划进行关节整形.
- 干预组接受了12周的高纤维饮食 (38g/天);对照组没有改变饮食.
- 测量包括BMI,HbA1c,血清骨标记物 (P1NP,CTX),骨微CT和RT-PCR用于基因表达.
主要成果:
- 与对照组相比,高纤维饮食组的BMI (4%) 和HbA1c (3.4%) 显著降低.
- 血清公原1型氨基终端 (P1NP),骨形成标记物,在高纤维组下降了8.6%.
- 没有观察到骨再吸收标记CTX,骨微架构 (脊椎和皮质) 或与Wnt通路和炎症相关的基因表达的显著变化.
结论:
- 12周的高纤维饮食干预有效地改善了T2DM患者的代谢控制 (BMI,HbA1c).
- 这种干预可能会对骨形成产生负面影响,如P1NP水平降低所示.
- 高纤维饮食没有改变骨微型结构或Wnt通路基因表达,这表明对骨形成标记物的特定影响,而不是整体骨结构或关键调节通路.
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