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评估非可预测突破性癌症疼痛现象的性别差异:IOPS-MS研究中的二次分析

Sabrina Bimonte¹, Piergiacomo Di Gennaro², Anna Crispo²

¹Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.

Journal of pain research

|September 10, 2024

概括

男性在胸部更频繁地经历突破性癌症疼痛 (BTcP),需要更高的阿片类药物剂量. 在BTcP呈现和治疗中,这些性别差异是显著的,特别是在转移性患者中.

科学领域:

在瘤学瘤学.
疼痛管理疼痛管理
临床研究临床研究

背景情况:

突破性癌症疼痛 (BTcP) 是一种突然的,严重的疼痛恶化,尽管定期接受阿片类药物治疗.
非可预测的BTcP (NP-BTcP) 发生在没有明确的触发因素的情况下.
现有证据表明,性别影响疼痛敏感性和癌症疼痛风险.

研究的目的:

调查和突出性别差异在非可预测突破癌症疼痛 (NP-BTcP) 的现象.
分析NP-BTcP的性别特征,包括疼痛强度,频率和类型.

主要方法:

意大利瘤疼痛多环境多中心调查 (IOPS-MS) 的二次分析.
关注非性别特异性癌症中的NP-BTcP病例.
单变量和多变量分析,包括转移性状态分层,以确定性别差异.

主要成果:

男性报告胸部BTCP发生率较高 (15%对11%) 和BTCP治疗剂量较高 (33%对28%).
男性的卡诺夫斯基分数较低 (46.9比49.2),表明表现状况较差.
在转移性患者中观察到类似的性别差异,涉及BTcP部位,发病,剂量和卡诺夫斯基评分.

结论:

在突破性癌症疼痛的部位,发作和剂量方面存在显著的性别差异.
对BTcP表型表征的进一步研究可能有助于管理癌症疼痛,特别是在非转移性患者中.

关键词:

集群分析集群分析集群分析性别癌症疼痛癌症疼痛不能预测的突破癌症疼痛癌症疼痛

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