将工业相关的海洋藻类Nannochloropsis变成红色:这是一个多方面的好处
Meijing Liu1,2, Lihua Yu2, Jie Zheng1
1Engineering Research Center of Watershed Carbon Neutrality of Ministry of Education, and Center for Algae Innovation & Engineering Research, School of Resources and Environment, Nanchang University, Nanchang, 330031, China.
The New phytologist
|September 10, 2024
概括
工程海洋微藻 Nannochloropsis oceanica 现在可以在没有压力的情况下产生高水平的素. 这一突破使得阿斯塔山丁和乙酸 (EPA) 的联合生产成为可持续生物技术的途径.
科学领域:
- 生物技术是生物技术.
- 海洋生物学 海洋生物学
- 代谢工程是代谢工程.
背景情况:
- 海洋藻 (Nannochloropsis oceanica) 是一种海洋微藻,富含有价值的eicosapentaenoic酸 (EPA).
- 目前从微藻中生产高价值化合物,如阿斯塔丁的方法有限.
- 释放N. oceanica的全部生产潜力对于工业应用至关重要.
研究的目的:
- 为了工程 Nannochloropsis oceanica 高水平的阿斯塔克桑丁合成独立于高光诱导.
- 为了在北大洋洲实现阿斯塔山丁和EPA的联合生产.
- 建立N. oceanica作为一个强大的底盘,用于可持续生产多种高价值的生物化学品.
主要方法:
- 对各种β-胡卜素基酶和基酶的查.
- 对酶分类,融合模式和链接器的战略操纵.
- 代代谢工程和食批量种植方法.
主要成果:
- 通过酶工程实现了133倍的阿斯塔山丁含量增加.
- 在非压力条件下,在N. oceanica中达到创纪录的7.3mgg-1阿斯塔桑.
- 由于阿斯塔克桑的整合,表现出增强的高光耐受性和增强的EPA生产.
- 成功联合生产了阿斯塔山丁和EPA.
结论:
- 海洋的Nannochloropsis可以被设计为一个光驱的底盘,用于构成性阿斯丁合成.
- 代谢工程策略使得阿斯塔克桑的产量显著增加.
- 从二氧化碳中同时生产多种高价值的生物化学品的可行策略被建立起来,为可持续生物技术铺平了道路.
相关概念视频
01:11Channel Rhodopsins
2.5K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.5K
00:46Bioremediation
18.2K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.2K