奎尔在糖尿病神经病变和视网膜病变中的治疗潜力:探索分子机制
Lunasmrita Saikia1, Sm Abdul Aziz Barbhuiya1, Kalyani Saikia1
1Faculty of Pharmaceutical Science, Assam down town University, Sankar Madhab Path, Gandhi Nagar Panikhaiti, Guwahati, 781026, Assam, India.
Current topics in medicinal chemistry
|September 10, 2024
概括
昆素是一种植物性黄类物质,通过减少氧化应激和炎症,在治疗糖尿病神经病变和视网膜病变方面表现有前途. 由于生物可用性挑战,需要进一步研究以优化其临床使用.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病是一种全球性健康问题,具有神经病变和视网膜病变等严重并发症.
- 奎尔是水果和蔬菜中发现的黄类物质,具有抗氧化,抗炎和神经保护性质.
- 这些特性表明糖尿病并发症的潜在治疗益处.
研究的目的:
- 审查瑞在糖尿病神经病变和视网膜病变中的疗效的分子机制.
- 巩固目前对奎尔丁对神经和视网膜组织的保护作用的理解.
- 确定对奎尔塞丁临床应用的挑战和未来研究方向.
主要方法:
- 在SciFinder,PubMed和谷歌学者中进行全面的文献搜索,截至2024年2月.
- 分析临床前研究,调查奎尔塞丁对糖尿病神经病变和视网膜病变的影响.
- 专注于涉及的分子通路和细胞机制.
主要成果:
- 奎尔素通过改善神经元功能和减少DNA损伤来减轻神经病痛和感官缺陷.
- 它通过抑制新血管化和防止细胞死亡来保护视网膜结构和功能.
- 奎尔胺调节AMPK激活和GLUT4上调等关键通路,减少氧化应激和炎症.
结论:
- Quercetin 通过其抗氧化和抗炎作用,显示出在改善糖尿病神经病变和视网膜病变方面的显著潜力.
- 特定分子通路的调制有助于其神经保护和视网膜保护作用.
- 有限的生物可用性是一个关键的挑战,需要进一步的研究以获得最佳的临床应用,剂量和配方.
更多相关视频
相关概念视频
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
01:22Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...