机器学习可以克服95%的失败率和现实,只有30%的批准的癌症药物有意义地延长患者的生存时间吗?
Duxin Sun, Christian Macedonia1, Zhigang Chen2
1Lancaster Life Science Group, Lancaster, Pennsylvania 17601, United States.
Journal of medicinal chemistry
|September 10, 2024
概括
癌症药物开发面临的失败率很高. 一个新的STAR引导的机器学习 (ML) 系统解决了提高药物成功和效率的关键因素.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 计算生物学 计算生物学
背景情况:
- 癌症药物开发在30年内有95%的失败率,经批准的药物对患者的生存益处有限.
- 现有的策略经常添加标准,而不去除不必要的标准,冒着生存偏见的风险.
- 机器学习 (ML) 提供了潜在的效率提升,但如果不解决故障的根本原因,可能无法提高成功率.
研究的目的:
- 引入一种新的"STAR引导的ML系统" (结构-组织/细胞选择性-活性关系),以提高癌症药物开发的成功率和效率.
- 解决成功开发药物至关重要的被忽视的相互依存因素:功效/特异性,组织/细胞选择性和最佳临床剂量.
- 通过整合这些关键因素来改善临床疗效和安全的预测.
主要方法:
- 开发一个"STAR引导的ML系统",整合结构-组织/细胞选择性-活性关系.
- 专注于三个相互依存的因素:有效性上的/非目标功效/特异性,不良反应的选择性上的/非目标驱动性,以及平衡有效性和安全性的最佳临床剂量.
- 利用ML模型中的五个关键特征来预测临床剂量,疗效和安全性.
主要成果:
- 由STAR指导的ML系统旨在直接预测临床剂量,疗效和安全性.
- 通过分析五个特定特征,该系统可以指导设计和选择更有效的癌症药物.
- 预计将提高癌症药物开发管道的成功率和效率.
结论:
- 拟议的STAR引导的ML系统提供了一种新的方法来克服癌症药物开发中的高失败率.
- 通过系统地解决功效,选择性和剂量问题,这种ML系统可以显著提高药物的疗效和安全性.
- 这种方法有望提高将新的癌症疗法带给患者的整体效率和成功.
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